Public Health
Cardium Therapeutics (NYSE Amex: CXM) and its subsidiary Tissue Repair Company (TRC) announced a presentation entitled "Phase 2b Study of GAM501 (Ad5PDGF-B/Collagen) in the Treatment of Diabetic Ulcers" at the Late Stage Industry Clinical Trials Symposium at the American Society of Gene Therapy (ASGT) Annual meeting in San Diego, California, on May 27, 2009. Dr. Barbara K. Sosnowski, Cardium"s Vice President of Biologics Development and the Chief Operating Officer of Cardium"s Tissue Repair Company Operating Unit, provided an update on TRC"s Phase 2b MATRIX clinical trial and the new formulation of the Excellarate(TM) product candidate, as well as an overview of the prior clinical study of Excellarate.
Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and serious virus infections, provided an update on progress in the company"s clinical program for Cotara(R), a targeted monoclonal antibody-based therapy being tested in a Phase II trial as a potential new treatment for recurrent glioblastoma multiforme (GBM), a deadly form of brain cancer. The company also reported that patient enrollment in the final cohort of a second Cotara GBM trial, a dose confirmation and dosimetry study, is nearing completion and that interim data from this trial has been accepted for an oral presentation at the Society of Nuclear Medicine Annual Meeting to be held June 13-18, 2009.
Scientists in Portugal and France managed to follow the patterns of gene expression in food-poisoning bacteria Listeria monocytogenes (L. monocytogenes) live during infection for the first time. The work about to be published in PLoS Pathogens shows how the bacterial genome shifts to better adapt to infection by activating genes involved in virulence and subversion of the host defences, as well as adaptation to the host conditions. This is the first time that the molecular interactions between L. monocytogenes and its host, as they occur during the different steps of infection, are followed in real time paving the way, not only to the development of new therapies against this potentially lethal bacterium, but also for the study of other pathogen/host interactions.
Advertisements from interest groups on health reform have increased in recent days, as the congressional session resumes next week and lawmakers continue to work on reform legislation, the New York Times reports. Spots from Health Care for America Now advocate coverage for all U.S. residents and a public health insurance option. One of the group"s ads is airing in Maine and urges viewers to contact Sens. Olympia Snowe (R) and Susan Collins (R) to express support for the public insurance option. The group has spent $200,000 on ads in the last month, according to spokesperson Jacki Schechner. Business Forward -- a new coalition that includes AT&T, Microsoft and IBM -- is running ads to encourage business executives to work with the Obama administration and congressional lawmakers in "reforming health care" (Pear, New York Times, 5/28). Also, Healthy Economy Now has an ad campaign to support reform efforts (Dann, CongressDaily, 5/27).Conservatives for Patients" Rights, a group founded by former Hospital Corporation of America CEO Richard Scott, has been airing a 30-minute video on cable networks showing British and Canadian doctors and patients who are not satisfied with their respective countries" health systems. The group is spending $1.2 million on the video and a campaign of short TV spots and earlier this year spent $2.5 million on similar ads, according to spokesperson Keith Appell. The Americans for Prosperity Foundation has spent $800,000 on television ads in eight states. In its spot, a woman from Canada describes her experience with the Canadian health system and how she ended up receiving treatment in the U.S. According to the Times, similar campaigns "helped sink President Clinton"s plan for universal coverage 15 years ago" (New York Times, 5/28).
Many U.S. hospitals do not take sufficient disciplinary action against physicians for poor conduct or medical incompetence and fail to report such cases to the National Practitioner Data Bank, according to a report released Wednesday by Public Citizen, the Contra Costa Times reports. Congress established the databank in 1990 as a central repository for information about physicians whose hospital privileges had been withdrawn or limited for more than 30 days. The bank is closed to the public (Kleffman, Contra Costa Times, 5/27).For the report, Public Citizen"s Health Research Group analyzed studies by the HHS Office of Inspector General and the Citizen Advocacy Center, as well as medical journal articles and recommendations made during an October 1996 meeting on under-reporting by hospitals (Stark/Hallihan, ABCNews.com, 5/27). According to the report, nearly half of U.S. hospitals did not submit one physician"s name in 17 years to the databank. One purpose of the databank is to provide hospitals with background information about physicians they were considering hiring at their facilities. Under the initial expectations of the databank, federal officials estimated that at least 5,000 disciplinary cases would be reported annually. However, on average, about 650 reports have been made annually since the databank was created, the report found (Contra Costa Times, 5/27). The group on Wednesday sent a letter to HHS Secretary Kathleen Sebelius that included recommendations to improve the efficacy of the databank. The letter said that the reporting numbers are "unreasonably low, compared with what would be expected if hospitals pursued disciplinary actions aggressively and reported all such actions." The letter urged Sebelius to ensure that hospitals are conducting necessary peer reviews and oversight of physicians, taking proper disciplinary actions and reporting them to the databank so that physicians" track records are available to all hospital administrators. Penalties also should be established for hospitals that fail to comply with the reporting requirements, the group said.Al Levine, the author of the report, said some hospitals had found ways to avoid their physician reporting responsibilities, such as by limiting restrictions on hospital privileges to fewer than 30 days or giving physicians a "leave of absence" in place of suspending their privileges. Levine said, "Even in states with high levels of reporting," it "seems to be concentrated in a few facilities" (Contra Costa Times, 5/27).In a statement responding to the report, the American Hospital Association said, "The premise that the number of reports received by the National Practitioner Data Bank correlates to jeopardized patient care is inaccurate," adding, "Hospitals are actively involved in a wide variety of efforts to continuously improve care and talk publicly about the care we provide" (ABCNews.com, 5/27).
"Nearly 30 years after the discovery of HIV and AIDS, the epidemic is still ravaging black neighborhoods in Baltimore and across the nation," Kevin Fenton -- director of CDC"s National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention -- writes in a Baltimore Sun opinion piece. Fenton writes that "complacency about HIV and the continued stigma associated with the disease are hindering progress by preventing too many African-Americans from seeking either HIV testing and treatment or support from their friends and family," adding that "this is a challenge that can be overcome."According to Fenton, the Obama administration last month "took an important step in confronting the United States" HIV epidemic" when CDC and White House officials announced a five-year campaign called Act Against AIDS, which is "designed to refocus the nation"s attention on the HIV crisis here at home." Fenton notes that 14 black civic organizations -- including the NAACP, the National Urban League, the Southern Christian Leadership Conference and the National Council of Negro Women -- are "joining the CDC to increase knowledge, awareness and action within black communities across the country." He adds that the campaign "will harness the strength and reach of these organizations by enhancing their ability to make HIV prevention a core component of their daily activities." "By raising the visibility of HIV and AIDS, the new campaign also aims to confront and overcome the fear and stigma that help keep HIV alive in black communities," Fenton says. He adds that he has "been encouraged in recent years to see black leaders, including black faith leaders, speak out more openly across the nation about the need to confront HIV and the stigma that persists surrounding this disease." Fenton writes that "[e]nding this epidemic will require not only frank and difficult discussions about HIV but also a shared sense of responsibility and commitment," concluding, "All of us can and must be part of the solution" (Fenton, Baltimore Sun, 5/27).
Low vitamin D levels in blacks could contribute to health gaps between white and black U.S. residents, Michael Holick, a professor at Boston University and a vitamin D researcher, said recently, the GNS/Chicago Sun-Times reports. According to Holick, blacks have lower levels of vitamin D than whites in part because the higher amount of pigment in their skin makes it harder for their body to absorb the nutrient, which is produced in response to sun exposure. Although scientists are debating optimum vitamin D levels, some scientists have said that vitamin D can reduce the risk of cancer, diabetes, heart disease and other illnesses. Holick added that some scientists believe blacks are more likely to have prostate cancer, breast cancer and colon cancer and have more aggressive forms of the cancer because they have lower levels of vitamin D. John Flack, principal investigator at the Center for Urban and African American Health at Wayne State University, said lower vitamin D levels among blacks is "potentially a very important explanation for some of the differences, from hypertension to cancer to heart failure," adding, "The actual proof is not there, but it"s plausible." Flack added that many factors -- including decreased access to health care and differences in income and education -- contribute to the overall poorer health among blacks. The Institute of Medicine next year is expected to release new guidelines on recommended daily intake for vitamin D. "All Americans, but particularly people with darker skin, should pay attention" to the new guidelines, according to Adit Ginde, a researcher at the University of Colorado Denver School of Medicine who led a recent study that found vitamin D levels are decreasing in all racial groups and are particularly low in blacks (Painter, GNS/Chicago Sun-Times, 5/28).
Mice carrying a "humanized version" of a gene believed to influence speech and language may not actually talk, but they nonetheless do have a lot to say about our evolutionary past, according to a report in the May 29th issue of the journal Cell, a Cell Press publication.
Two studies in the May 29th issue of Cell, a Cell Press publication, have taken advantage of new technological advances to search for and find previously unknown weaknesses in a hard to treat form of cancer. The discoveries lend new hope in the fight again tumors that are today considered "undruggable."
Mothers who share cancer genetic test results with their children are more satisfied with their decision than those who decide not to tell, according to a new study by researchers at the Lombardi Comprehensive Cancer Center at Georgetown University Medical Center. The study also shows, for the first time, what role fathers play in disclosing mother"s test results. These findings will be presented at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Orlando May 29 - June 2.
Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer.
When someone becomes dependent on drugs or alcohol, the brain"s pleasure center gets hijacked, disrupting the normal functioning of its reward circuitry.
Sensory ataxic neuropathy (SAN) is a recently identified neurological
Here"s one more reason to keep your teeth healthy.
Small Bone Innovations, Inc. (SBi), a leading provider of innovation, products, technology and education for the small bone & joint segment of the orthopedics industry, announced that the U.S. Food and Drug Administration (FDA) has approved SBi"s Scandinavian Total Ankle Replacement (S.T.A.R.®) system to treat U.S. patients. S.T.A.R. has received pre-market approval (PMA) to replace a painful arthritic ankle joint due to osteoarthritis, post-traumatic arthritis or rheumatoid arthritis.
UK researchers who reviewed pooled clinical trial data covering 95,000 people concluded that there was no net benefit to healthy people taking
Frequent air travelers, as well as people who fly only occasionally, are often inconvenienced by the effects of jet lag, according to research presented today at the American College of Sports Medicine"s 56th Annual Meeting in Seattle. Christopher Berger, Ph.D., Chair of the American College of Sports Medicine (ACSM) Task Force on Healthy Air Travel, "Exercise is Medicine™ On the Fly," explains that jet lag, medically called desynchronosis, is the physiological response to alterations to circadian rhythms.
The U.S. Food and Drug Administration approved Besivance (besifloxacin ophthalmic suspension 0.6 percent) for the treatment of bacterial conjunctivitis (non-viral), a contagious condition marked by irritation of the eyes and a discharge from the mucous membranes.
Sleep disturbances increase as we age. Some studies report more than half of seniors 65 years of age or older suffer from chronic sleep disturbances. Researchers have long believed that the sleep disturbances common among the elderly often result from a disruption of the body"s circadian rhythms - biological cycles that repeat approximately every 24 hours.
Bayer Healthcare Pharmaceuticals Inc. announced that several studies evaluating the use of Leukine(R) (sargramostim) will be presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting.
CuraGen Corporation (Nasdaq: CRGN) announced plans for three data presentations from its ongoing clinical trials of CR011-vcMMAE, an antibody-drug conjugate that targets GPNMB, in patients with advanced breast cancer and melanoma at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida.
Many cases of age-related neurodegenerative disease fall into the gray zone between big, defined diseases - Alzheimer"s or Parkinson"s, for example. Their diagnostic accuracy is low, researchers agree. That"s a problem, because mixed disease is not only common, but also quite different in its course from pathologically "pure" disease. (Mixed disease is often worse.) But there"s also excitement and opportunity. The large overlap between established neurodegenerative diseases is ripe for scientific exploration, and recent advances at the genetic, clinico-pathologic, and molecular levels have turned it into a dynamic area of research. In particular, diseases such as Dementia with Lewy bodies and frontotemporal dementias are drawing intense interest as biomarker development branches out beyond Amyloid beta and tau, holding out a future where molecular-based diagnoses can define the pathogenic proteins that together drive a given person"s individual disease.
By using ultrafast laser pulses to slice off pieces of chromosomes and observe how the chromosomes behave, biomedical engineers at the University of Michigan have gained pivotal insights into mitosis, the process of cell division.
UroToday.com - This updated review of tadalafil (Cialis), one of the three available phosphodiesterase type 5 (PDE5) inhibitors that revolutionized the treatment of erectile dysfunction (ED), analyzes its latest clinical studies. Tadalafil"s most unique and identifying characteristic is its long half-life of 17.5 hours, compared with 4 hours for sildenafil (Viagra) and vardenafil (Levitra).
CAFFEINE SHOWN AS EFFECTIVE AT REDUCING EXERCISE-INDUCED ASTHMA SYMPTOMS AS AN ALBUTEROL INHALER
A new study is the first to show that there is a previously unrecognized role for environmental pollution in liver disease in the general U.S. adult population. This work builds upon the groups" previous research demonstrating liver disease in highly-exposed chemical workers. The study is being presented during Digestive Disease Week® 2009 (DDW®), the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
The Nevada Assembly last week voted to approve a bill (SB 229) that would authorize the Nevada Department of Health and Human Services to stop the exploitation of foreign physicians who have come to the state to provide care to residents in underserved areas, the Las Vegas Sun reports. The measure now goes to Gov. Jim Gibbons (R) for his approval (Allen, Las Vegas Sun, 5/28). A September 2007 Sun investigation of the J-1 visa program found that some foreign physicians were forced by their sponsors to work up to 100 hours per week, and were being "cheated out of their salaries" and "diverted from the patients" in underserved areas whom they were supposed to help (Kaiser Daily Health Policy Report, 8/6/08).The legislation would make violations of the J-1 program more clearly punishable under state law and prosecutable by the attorney general"s office; charge J-1 physician sponsors a fee to cover the cost of enforcing the law; and protect whistle-blowers (Las Vegas Sun, 5/28).
Botswana"s campaign to circumcise about 500,000 men by 2012 will prevent nearly 70,000 new HIV cases by 2025, according to a report published Thursday in the Journal of the International AIDS Society, AFP/Yahoo! News reports. The government"s national campaign aims to circumcise 460,000 men over the next five years, and the country has begun airing television and radio advertisements to encourage men to be circumcised at local clinics. "Scaling up safe male circumcision has the potential to reduce the impact of HIV/AIDS in Botswana significantly," according to the study. The report puts the estimated cost of the circumcision campaign at about $47 million. A UNAIDS report estimates that the HIV prevalence among pregnant women in Botswana was 43% in 2003, the year that antiretroviral drug access was introduced in the country (AFP/Yahoo! News, 5/28).
Isaac Muliloa -- national coordinator of the HIV and sexually transmitted infections unit at the Solomon Islands" Ministry of Health -- recently said that a lack of national HIV/AIDS laws is hindering efforts to address the disease, the Solomon Times reports. Recent World Health Organization estimates said that the number of HIV cases in the Solomon Islands could reach 350 by 2010. Muliloa said that legislation is needed to address continued discrimination against HIV-positive employees in the workplace. He added that the HIV/AIDS and STI unit is relatively new in the health ministry, as is the Solomon Islands" National AIDS Council. According to Muliloa, officials are continuing to work toward implementing policies. The Times reports that the Solomon Islands does not have laws in place criminalizing the intentional transmission of HIV (Solomon Times, 5/27).
Sodexo (PARIS:SW) (OTCBB:SDXAY) received two awards at the inaugural Professional Training Evening held May 25 in Paris: the "Best Training Strategy" award and the Favorites Award for "Successful vocational rehabilitation." The culmination of a 75-company competition, the event was organized jointly by France"s National Association of Human Res Directors (ANDRH), Professional Training Federation (FFP) and Association of Trainers and Training Managers (GARF).
What
UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders, some of which increase risk for several types of cancer.
Linking genetic material microRNAs with cells that regulate the immune system could one day lead to new therapies for treating cancer, infections and autoimmune diseases, according to a Henry Ford Hospital study.
The Institute of Medicine and the National Research Council on Thursday issued revised U.S. weight-gain guidelines for obese pregnant women, in response to rising levels of obesity in the country and growing evidence that weight gain can cause health problems for women and their infants, the New York Times reports. The revision, which is the first since 1990, recommends that obese women -- those with a body mass index of 30 or more -- limit their weight gain to 11 to 20 pounds over nine months. The 1990 pregnancy guidelines did not specifically address weight gain for obese women, telling them instead to follow the recommendations for overweight women. According to health officials, the changes to the recommendations for obese women were required to keep up with the changing weight patterns among women in the U.S. The New York Times reports that about 27% of women of childbearing age are considered obese, while 55% fall into the categories of overweight or obese.The recommendations for women with BMIs of less than 30 did not change. They call for overweight women -- those with a BMI of 25 to 29.9 -- to gain 15 to 25 pounds over nine months, while underweight women -- with BMIs of less than 18.5 -- should gain 28 to 40 pounds, and normal-weight women -- with BMIs of 18.6 to 24.9 -- should gain 25 to 35 pounds (Parker-Pope, New York Times, 5/29).Time reports that pregnant women who do not gain enough weight face a higher risk of stunted fetal growth and preterm delivery. However, it is more common for women to gain too much weight, placing them at higher risk for conditions like gestational diabetes and high blood pressure. In addition, their infants are at increased risk of being born earlier, larger and by cesarean section. Time reports that excessive weight gain can increase a woman"s risk of postpartum obesity and elevate risks of heart disease and stroke because most women do not lose extra pounds gained during pregnancy. Many studies also have suggested that a woman"s gestational weight can predict potential weight problems in her offspring (Kingsbury, Time, 5/28).The committee that developed and issued the revision said that the existing guidelines were essentially on target but that women and their physicians need to work harder to help women reach a normal weight before pregnancy and avoid gaining too much weight during pregnancy, according to the Los Angeles Times (Roan, Los Angeles Times, 5/29). The guidelines also recommend more nutrition and exercise counseling during pregnancy, advising physicians or midwives to consult dieticians to shape a woman"s care regardless of her initial weight, the AP/Yahoo! News reports (Neergaard, AP/Yahoo! News, 5/28). The Los Angeles Times reports that health care professionals are expected to recognize and implement some of the recommendations; however, it is not mandatory to do so.Several experts on maternal obesity and child health expressed disappointment with the guidelines, arguing that obese women should gain little to no weight during pregnancy, according to the Los Angeles Times. They also argue the new guidelines do not do enough to address obesity before pregnancy. Maxine Hayes, state health officer for the Washington State Department of Health, said, "If we wait for every woman to be advised about weight gain after they become pregnant, it"s too late. It puts women and their babies on a trajectory that is unhealthy" (Los Angeles Times, 5/29).
A program aimed at reducing criminal behavior in juvenile justice teens has yielded a surprising side benefit. The program is also reducing the teens" rate of pregnancy, according to a new study out this week.
A study in the June 1 issue of the journal SLEEP demonstrates that online cognitive behavioral therapy (CBT) for chronic insomnia significantly improves insomnia severity, daytime fatigue, and sleep quality. Online treatment also reduces erroneous beliefs about sleep and pre-sleep mental arousal.
A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients.
If you had cancer and a genetic test could predict the risk of the tumor spreading aggressively, would you want to know - even if no treatments existed to help you?
Data presented at the 2009 American Transplant Congress
Patients with esophageal cancer who require surgery may benefit from having minimally invasive surgery instead of an open esophagectomy, or removal of the esophagus, according to a University of Pittsburgh Cancer Institute (UPCI) phase II study. The results will be presented May 31 at the 45th annual meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Fla.
Spending hours taking a high-pressure aptitude test may make people feel mentally fatigued, but that fatigue doesn"t necessarily lead to lower test scores, according to new research published by the American Psychological Association. If anything, performance might actually improve on a longer test, the study found.
South Australia has the dubious distinction of receiving the AMA"s annual Dirty Ashtray Award for the Australian State or Territory that made the least progress on combating smoking during 2008.
New data published this week in Expert Opinion Pharmacotherapy has revealed that Next Generation FlexPen®, Novo Nordisk"s prefilled insulin delivery device, has a significantly lower injection force than two other devices, SoloStar® and KwikPen®.(1,2,3) Previous studies show that people with diabetes prefer a lower injection force.(4,5)
Even while their blood pressures are still normal, overweight male teens may have elevated levels of a hormone known to increase pressures as well as early signs of heart damage, researchers say.
If having malodorous armpits (called osmidrosis) and goopy earwax isn"t bad enough, a discovery by Japanese scientists may add a more serious problem for women facing these cosmetic calamities. That"s because they"ve found that a gene responsible for breast cancer causes these physical symptoms. The report describing this finding is featured on the cover of The FASEB Journal"s June 2009 print issue, and should arm physicians with another clue for detecting breast cancer risk.
The prevalence of overweight in the US population is among the highest in Mexican-American children and adolescents. In a study of 1,030 Hispanic children between the ages of 4 and 19, published in the June 2009 issue of the Journal of the American Dietetic Association, researchers from the Baylor College of Medicine found less than optimal diets in both overweight and non-overweight participants.
Soccer players and exercise enthusiasts now have another reason to reach for lowfat chocolate milk after a hard workout, suggests a new study from James Madison University presented at the American College of Sports Medicine annual meeting. Post-exercise consumption of lowfat chocolate milk was found to provide equal or possibly superior muscle recovery compared to a high-carbohydrate recovery beverage with the same amount of calories.
The following statistics were released by the Department of Health:
Insurance companies, "the industry that gets credit for helping to kill the Clinton administration"s health care overhaul 15 years ago," are now "striking a conciliatory tone as it faces the most serious attempt to overhaul the system since that effort collapsed," CQ Politics reports. With low favorability ratings and Democrats in control of the federal government, "insurers know they aren"t in a good bargaining position" this time around. They have already offered concessions, including providing "insurance in the individual markets to everyone, without regard to who is sick," and not "charging people who are ill higher rates and cut health care costs." But they"ve also been ""careful to structure their offers in such a way that appears significant but does not overpromise." An individual mandate for all Americans and an end to health screening for applicants could offer "a win-win outcome, one that will benefit not just patients but potentially the profits of the industry as well." But "perhaps the biggest motivation for insurers to deal now is that they fear what might happen if they don"t" - the "creation of a government-run plan that would be more attractive to the public and siphon off customers" (Adams, 6/1).
Nancy-Ann DeParle, director of the White House Office of Health Reform, predicted in an interview with Kaiser Health News that a comprehensive health care reform bill would reach President Obama by Thanksgiving, and that she hasn"t given "a moment"s thought" to accepting a scaled-back package.
The New York Times reports on a series of deep budget cuts to help California, which is some $24 billion in the red, deal with its" ongoing financial woes.
Implementing measures to improve nutrition, indoor air pollution, immunization coverage and the management of pneumonia cases could be cost-effective and significantly reduce child mortality from pneumonia, according to a study led by the Johns Hopkins Bloomberg School of Public Health. Researchers found that these strategies combined could reduce total child mortality by 17 percent and could reduce pneumonia deaths by more than 90 percent. Pneumonia is a leading cause of death of infants in many developing countries, resulting in 2.2 million deaths each year. The study is published in the June 2009 issue of the Bulletin of the World Health Organization.
GTx, Inc. (Nasdaq: GTXI) announced the presentation of data demonstrating that toremifene 80 mg treatment compared to placebo increased bone mineral density (BMD) in multiple clinically relevant subpopulations of men with prostate cancer on androgen deprivation therapy (ADT). The data, an analysis of results of the recent Phase III clinical trial evaluating toremifene 80 mg for the prevention of bone fractures and treatment of other estrogen deficiency side effects of androgen deprivation therapy in men with prostate cancer, were presented yesterday at the 2009 Annual Meeting of the American Society of Clinical Oncology.
The Santa Maria Times examines how California Gov. Arnold Schwarzenegger"s (R) plan to reduce state spending by more than $5 billion over the next two fiscal years, which includes millions of dollars in funding cuts to HIV prevention, education and treatment programs, could affect county residents (Womack, Santa Maria Times, 5/31). According to the Times, hundreds of residents in Santa Barbara County -- including more than 100 AIDS Drug Assistance Program (ADAP) clients -- would potentially be affected by the funding cuts (Santa Maria Times, 5/31). The proposal also would result in $1.8 million in cuts to programs for low-income residents living with HIV in Riverside County, the Desert Sun reports (Brambila, Desert Sun, 5/29). The plan, issued by Schwarzenegger last week, includes $55.5 million in cuts to California"s ADAP and other state Office of AIDS programs (Kaiser Daily HIV/AIDS Report, 5/27).
Some New York City residents with HIV pay as much as 70% of their income on housing because of the financial assistance they receive through the New York City HIV/AIDS Services Administration, New York Daily News columnist Errol Louis writes. According to Louis, lawmakers should pass a bill that would cap the rent contribution of low-income people with HIV/AIDS at 30% of their income, "the standard used for most rent-subsidy programs." The bill is currently before the state"s Assembly Ways and Means Committee. Louis adds that ensuring that people living with HIV are in "stable housing ò€¦ makes them less likely to run up big taxpayer bills by using public hospital emergency rooms for basic health care." He concludes, "Albany has a choice: do what"s cheap and quick in the short run, or do what makes long-term sense and saves lives" (Louis, New York Daily News, 5/31).
A group of Senate Democrats will meet with President Obama today to discuss overhauling health care, The New York Times reports.
PharmAthene, Inc. (NYSE Amex: PIP), a biodefense company developing medical countermeasures against biological and chemical threats, announced that it has submitted a proposal to the Biomedical Advanced Research and Development Authority (BARDA) in response to a Broad Agency Announcement (BAA-BARDA-09-34) for advanced research and development of medical countermeasures for chemical, biological, radiological and nuclear threats. PharmAthene has requested funding to further develop Valortim(R), a fully human monoclonal antibody, for the prevention and treatment of anthrax infection. To date, the Company has received funding commitments from the U. S. government totaling up to $24 million to advance the development of Valortim(R).
B. Braun Medical Inc. (B. Braun), a leader in infusion therapy and pain management, said today it anticipates U.S. Food and Drug Administration (FDA) approval for 2g Cefazolin for Injection USP and Dextrose Injection USP in B. Braun"s DUPLEX(R) Drug Delivery System.
The University of Cincinnati houses internationally and nationally ranked programs in design, business and engineering; and faculty and students from these cutting-edge programs recently took on a project to design better hospital gowns in partnership with Hill-Rom Company, Inc., of Batesville, Ind., a maker of hospital beds and medical equipment.
CSC (NYSE: CSC) announced that it has expanded its FirstPortfolio solution"s business process outsourcing (BPO) capabilities to include fully integrated Medicare Secondary Payer (MSP) reporting for healthcare payers. FirstPortfolio provides users with a collection of applications hosted and maintained by CSC.
Reuters reports that, due to the difficulties in getting or paying for health insurance, "countless workers in the United States are trapped in jobs they would like to leave ... calcifying innovation and mobility in the world"s largest economy." Reuters notes that when he was head of the National Federation of Independent Businesses, "Todd Stottlemeyer frequently encountered would-be entrepreneurs who let their ideas go stale and their products languish on the workbench because they did not want to shoulder their own health care costs. "
Jamaica has already achieved some U.N. Millennium Development Goal (MDG) targets and is "on track" to attain five more, according to a report that mapped the country"s progress toward the MDGs, the Jamaica Observer reports.
The Washington, D.C. HIV/AIDS Administration (HAA) will increase its HIV-related media efforts targeting those at risk for the virus amid a recent finding by the agency that 3% of the district"s residents are living with HIV/AIDS, the Washington Post reports. Mayor Adrian Fenty recently committed $500,000 annually for a five-year marketing campaign, Shannon Hader, director of HAA said. Advertising experts say that millions more would be needed in order for the agency to have an "effective" campaign, or that local media, billboard companies and the district"s Metro system need to provide more free advertising space, according to the Post. Next month HAA plans to announce a campaign targeting heterosexual couples that will encourage HIV testing (Fears, Washington Post, 6/2).
Declining private and public financial support has forced Vital Life Services, an Oakland, Calif.-based nonprofit that provided support, case management, mental health counseling and other services to roughly 400 low-income and homeless clients with HIV, to shut down, the Oakland Tribune reports. According to the Tribune, the 25-year-old center -- which also provided "unique" services such as daily meals and emergency housing assistance -- "has become a victim of the recession" (Burt, Oakland Tribune, 5/30).
The World Medical Association has urged the President of Sri Lanka to intervene on behalf of three government employed doctors, two of whom have been detained and the third taken to an unknown destination, after working in the conflict zone in Sri Lanka.
Older people in Britain are being drugged and robbed when they need care.
Registration forms for the prereg trainee pharmacist programme 2009/10 are now available to download on the NPA members" website. The NPA is also providing training on 26 June 2009 for prereg tutors that have enrolled their prereg on to the NPA"s programme.
A closer look at regulatory and clinical concerns with generic immunosuppression medications in thoracic transplantation is required, according to an educational advisory by the International Society for Heart and Lung Transplantation (ISHLT) in the July 2009 issue of The Journal of Heart and Lung Transplantation, published by Elsevier.
An international team of astronauts, including Canadian Dr. Robert Thirsk who launched into space on May 27, have just published an article in the Canadian Medical Association Journal (CMAJ) about the complex physiologic changes and psychological effects that occur in space. They draw upon first-hand experience as both physician-astronauts and crew medical officers on space missions and from NASA literature and peer-reviewed medical s.
The scientific and medical publisher, BMJ Group, is to publish additional themed editions of the British Journal of Sports Medicine (BJSM), supported by the International Olympic Committee (IOC), it was announced today.
New data on the persistence of avian influenza viruses in the environment has allowed a team of University of Georgia researchers to create the first model that takes into account both direct and indirect transmission of the viruses among birds. The model, which is detailed in the early online edition of the journal Proceedings of the National Academy of Sciences, has the potential to shed new light on how outbreaks begin in wild bird populations.
People with lower back pain are better off exercising more, not less.
Infertility Network Scotland has welcomed the announcement by the Public Health Minister, Shona Robison, that over the next three years the Scottish Government will provide funding to Infertility Network Scotland to work with Health Boards to help them to address the inequity of access that has existed in Scotland for too many years. We also welcomed the news that an expert advisory group will be established this summer to consider an action plan on infertility services.
New research published by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme has found that while ibuprofen and paracetamol is more effective when used together when treating fever in pre-school children, ibuprofen should be used first as this will reduce the temperature quicker.
Based on the top-level analysis of a Phase II study, EyeGate Pharma announces that EGP-437, a corticosteroid solution administered by a non-invasive ocular drug delivery system, improved signs and symptoms in patients with dry eye syndrome (DES).
Wireless, personal computers used by cancer patients to log their symptoms help improve the patients" care and further cancer research, according to a study led by researchers in the Duke Comprehensive Cancer Center.
The European Society of Cardiology Congress 2009, the world"s biggest international meeting in Cardiology will be held in Barcelona, Spain, from 29 August to 2 September.
An innovative University of Georgia graduate program in special education that has prepared scores of Georgia teachers to work with elementary-age students with autism over the last several years has received a new 4-year, $793,000 federal grant to train teachers to work with similarly challenged secondary-age students.
Traumatic brain injury - not heart disease, stroke or cancer - is the number one cause of death and disability in people under 45. Each year, some 1.5 million Americans, including soldiers, athletes, the elderly and children, sustain head injuries, and nearly half of them will be hospitalized and treated in an emergency room or intensive care unit.
The Gamida Cell-Teva Joint Venture have today that five prestigious cord blood transplantation centers in Spain, three in Barcelona and two in Valencia, have joined the ExCell study.
After a review of 284 cases, specialists at the Brain Tumor Center at the University of Cincinnati (UC) Neuroscience Institute have concluded that performing a stereotactic needle biopsy in an area of the brain associated with language or other important functions carries no greater risk than a similar biopsy in a less critical area of the brain.
PeriCor Therapeutics, Inc. announced that positive preclinical results of its novel cardioprotective agent, GP531, were reported in a poster presentation by Hani N. Sabbah, Ph.D., at the European Heart Failure Congress 2009 in Nice, France. The study was funded by PeriCor Therapeutics, Inc. and conducted by Dr. Sabbah and colleagues at the Division of Cardiovascular Medicine of the Henry Ford Health System, Detroit, Michigan. GP531 is an investigational drug under development by PeriCor Therapeutics under an Investigational New Drug (IND) application.
Stiefel Laboratories, Inc. announced the completion and analysis of a pivotal phase III clinical trial for Hyphanox(TM) (itraconazole) tablet. The 200 mg itraconazole tablet formulation was developed using the proprietary Meltrex(R) technology.
Today, GlaxoSmithKline (GSK) announced the results of a Phase III study demonstrating that pazopanib reduced the risk of tumour progression or death by 54% compared to placebo.1
Abortion providers are expressing concern about future violence and access to abortion services later in pregnancy after the shooting death on Sunday of Kansas abortion provider George Tiller, the AP/San Diego Union-Tribune reports. Tiller was one of a handful of abortion providers in the U.S. who performed abortions in the third trimester of pregnancy. Tiller"s family members said they are unsure if they will reopen the clinic, which was closed after the murder (AP/San Diego Union-Tribune, 6/3). Dan Monnat, the attorney representing Tiller"s family, said that the family"s "hope is that the valuable work of Dr. Tiller will be able to continue," and that their "focus ... is to determine what is in the best interests of the employees and the patients" (Riccardi, Chicago Tribune, 6/3).Physician LeRoy Carhart said that he would like to continue to provide women with third-trimester abortion services at Tiller"s clinic, where he regularly traveled for a few days every three weeks to see patients. Carhart said that Tiller"s clinic was the only location where he performed abortions in the third trimester, and it is unclear whether he will be able to continue to offer the procedure because of the clinic"s closing. Carhart added that the continued availability of third-trimester abortion is uncertain, as many physicians in the younger generation of abortion providers are hesitant to take up the cause. Few schools and universities offer programs to train physicians to perform the procedure, and those who might be interested are concerned about violence, Carhart said (AP/San Diego Union-Tribune, 6/3). According to NPR"s "All Things Considered," U.S. marshals have been sent to protect abortion clinics and providers throughout the country in the wake of Tiller"s murder.Some abortion-rights supporters called on officials to do more to draw attention to the effects of violence on access to abortion services. Abortion provider Warren Hern, a friend of Tiller"s who also performs the procedure during the third trimester, said that President Obama needs to do more than condemn Tiller"s murder and violence against abortion providers. He said that Obama "needs to go on a national television broadcast and say to the American public, "Safe abortion is a fundamental component of women"s health care. Antiabortion terrorism and violence will not be tolerated. We will stop you."" Nancy Northup, president of the Center for Reproductive Rights, said, "We need to hear from our officeholders, from doctors, from religious leaders, from the community." She added, "(W)e can"t stop the voices of those who will continue to vilify and demonize, but what we can do is we need to have more voices standing up for these doctors" (Lohr, "All Things Considered," NPR, 6/2).Suspect Charged Kansas prosecutors on Tuesday formally charged Scott Roeder with murder for allegedly killing Tiller, the Chicago Tribune reports. The charge carries a maximum sentence of life in prison because the crime does not fit the state"s legal requirements for the death penalty, Sedgwick County District Attorney Nola Foulston said. The charges against Roeder also include two counts of aggravated assault for wielding his firearm at two individuals who tried to stop him (Chicago Tribune, 6/3).
On the same day President Obama expressed the urgent need for health care reform, he also met with two dozen Senate Democrats and suggested that he is open to considering taxing employer-provided health benefits to pay for health care reform, The Washington Post reports.
"With a health reform at the top of the Congressional and White House agenda, it"s prime time for industry lobbyists," Roll Call reports. But, because details of the anticipated reform package have not yet emerged, industry winners and losers remain largely unknown. Lobbyists are forced to accept clients despite their incomplete knowledge of client needs, and are struggling to anticipate conflicts of interest before they arise, according to the article. "There are so many different players at the table, and right now not knowing whose ox is likely to get gored and at whose expense... the best we can do is try and anticipate conflicts and be clear with our clients in advance," one health care lobbyist told the paper. "We certainly would not lobby on both sides of an issue. It"s also entirely possible conflict may emerge in the next two to six months, and we hope we don"t have to make hard choices" (Ackley, 6/3).
Navajo County Public Health Services District officials announced today the first case of 2009 H1N1 in Navajo County. The Arizona Department of Health Services Lab confirmed that an 18 year old patient at Little Colorado Medical Center tested positive for the illness. The patient has subsequently been treated and released.
New findings throw light on how the brain heals itself and may change the way we think about treating chronic neurodegenerative diseases like Parkinson"s and Alzheimer"s.
Cancer survivors of all ages will celebrate life on June 14 to show the world that life after a cancer diagnosis is not only possible, but it can be positive, productive and meaningful. From 10:30 a.m. to 5:00 p.m., in Bloch Cancer Survivors" Park on Harbor Island, cancer survivors, their families, healthcare professionals and the general public will take part in the 12th Annual Celebration of Life, hosted by Cancer Survivorship: San Diego!
Data was announced today that demonstrated Salix Pharmaceuticals" (NASDAQ:SLXP) APRISO™ (mesalamine) 0.375g extended-release capsules had a favorable safety profile in patients in remission from ulcerative colitis (UC) for up to 24 months. APRISO is approved for use up to six months. The majority of treatment-emergent adverse events were mild or moderate in intensity, and were similar to what was seen during the 6-month phase 3 trials. The study, which is the first to examine the long-term safety profile of APRISO, was presented at the Digestive Disease Week (DDW) annual meeting in Chicago, Illinois.
A simple magnetic resonance imaging (MRI) test involving breathing oxygen might help oncologists determine the best treatment for some cancer patients, report researchers at UT Southwestern Medical Center.
BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX), which is developing a testosterone gel (LibiGel®) for the treatment of hypoactive sexual desire disorder (HSDD) in menopausal women, today commented on a paper published in the May 15, 2009 issue of AIDS, the Journal of the International AIDS Society, on the effect of testosterone in women infected with HIV. The peer-reviewed journal reported results of a randomized, placebo-controlled trial of testosterone in HIV-infected women indicating that long-term testosterone administration was well tolerated in HIV-infected women and resulted in significant improvement in body composition, bone mineral density (BMD), and quality of life indices.
Sleeping tablets have been associated with a four-fold increase in suicide risk in the elderly. Researchers writing in the open access journal BMC Geriatrics have shown that, even after adjusting for the presence of psychiatric conditions, sedatives and hypnotics were both associated with an increased risk of suicide.
A promising antimicrobial agent already known to kill bacteria can also kill viruses and stimulate the innate immune system, according to researchers at National Jewish Health. In a paper appearing online June 4 in the Journal of Investigative Dermatology, Michael Howell, PhD, Assistant Professor of Pediatrics, and his colleagues demonstrated that the synthetic compound CSA-13 can kill vaccinia virus in cell cultures and in mice. Additionally, they showed that CSA-13 stimulates cells to produce their own antimicrobial proteins.
Results from a Phase III study presented at the American Society for Clinical Oncology (ASCO) Annual Meeting in Orlando, Florida today show that patients with advanced non-small cell lung cancer (NSCLC) who received erlotinib (Tarceva®) as first-line maintenance treatment benefited from a significant (29%) improvement in the time they lived without the disease advancing, compared with those who received placebo1. Patients in the global multicentre SATURN trial, which included patients from the UK, received maintenance treatment with erlotinib if their cancer had not progressed on initial chemotherapy. The data showed a significant improvement in the length of time patients lived without their disease getting worse, and without the need for further chemotherapy. 1 The improvement was seen in both of the main types of NSCLC (squamous cell as well as non-squamous cell) and these results form the basis of a submission for regulatory approval of erlotinib to be used in the first-line maintenance setting. 1 Erlotinib is not currently licensed for first line maintenance treatment in NSCLC lung cancer in the UK.
Data from 7 prucalopride trials are being presented at the Digestive
Children are especially vulnerable in the hospital and they are the population at highest risk of a medication error, according to the American Academy of Pediatrics. Meeting their needs in this environment can be especially challenging. The Joint Commission and Joint Commission Res (JCR) "Pediatric Conference: Safe Care, Quality Care, We Care" will help health care organizations review current pediatric emergency and perioperative services as benchmarks to improve their organizational approaches. JCR is a not-for-profit affiliate of The Joint Commission.
Metal-on-metal hip replacement and resurfacing have become the most commonly used type of procedure in the United Kingdom for patients who are Read the full text article.
Published recently is a study investigating the use of percutaneous vertebroplasty as a treatment for osteoporotic compression fractures. Vertebral compression fractures are a common complication of osteoporosis and can cause extreme pain and limit movement. Type-II fractures are often resistant to non-operative treatments and therefore the authors wanted to investigate percutaneous vertebroplasty as a pain management technique in these cases.
Hip resurfacing can be a good alternative to total hip replacement (THR) in young adults because it conserves bone and it has acceptable short- to medium-term results. However, there have been concerns about fractures of the femoral neck with this procedure, partly due to notching and varus alignment during implantation.
In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
A new review published in the Journal of Human Nutrition and Dietetics assessed whether certain modifications in diet have a beneficial effect on the prevention of prostate cancer. Results suggest that a diet low in fat and red meat and high in fruits and vegetables is beneficial in preventing and treating prostate cancer.
Your immune system plays an important function in your health - it protects you against viruses, bacteria, and other toxins that can cause disease. In autoinflammatory diseases, however, the immune system goes awry, causing unprovoked and dangerous inflammation. Now, researchers from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, and other institutions have discovered a new autoinflammatory syndrome, a rare genetic condition that affects children around the time of birth. The findings appear in the current issue of the New England Journal of Medicine.
ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), announced that new Thiarabine preclinical efficacy data will shortly be published demonstrating that thiarabine combined with clofarabine provides much greater antitumor activity than achieved by either agent alone. In one colorectal cancer model, 66% of mice were cured of their tumors. The publication which will appear in the journal "Cancer Chemotherapy and Pharmacology," was based on work conducted by Access" collaborators at the Southern Research Institute. The paper is entitled "Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]-cytosine" (thiarabine).