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2009/043 NICE Issues Guidance To Help Healthcare Professionals Identify Child Maltreatment
NICE has issued guidance to help healthcare professionals to identify children who may have been maltreated. The guidance provides a summary of alerting features that should prompt a healthcare professional to consider, suspect or exclude child maltreatment. Child maltreatment includes neglect, physical, sexual and emotional abuse, and fabricated or induced illness.
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Republicans Scold HELP Democrats Over Reform Bill's Price Tag, Government Control
"It was particularly devastating on Wednesday when [Sen. Orrin Hatch, R-Utah]" - a longtime friend of Sen. Edward Kennedy, D-Mass., - "warned Democrats on the panel that they have already made some grave errors in their effort to write legislation overhauling the health care system," reports the New York Times in The Caucus Blog. "Now unfortunately we are beginning a partisan exercise on perhaps the most important legislation of our lives," Hatch said during a meeting of the Senate Health, Education, Labor and Pensions Committee yesterday (Herszenhorn, 6/17).
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Latest Updates From The Alzheimer's Disease Neuroimaging Initiative (ADNI)
Alzheimer imaging aficionados thronged to back-to-back meetings held recently in Seattle for a preview of the latest data from the Alzheimer"s Disease Neuroimaging Initiative (ADNI). Launched in the fall of 2004 and set to conclude next year, the $64-million ADNI is comparing imaging methods and fluid biomarkers in the same set of people to determine which measures can best predict and track Alzheimer-disease clinical changes over time. The project is approaching the homestretch of data collection. By the fall of 2010, ADNI scientists will have collected three years of longitudinal data from more than 800 participants (about 200 normal, 400 with mild cognitive impairment (MCI), and 200 with Alzheimer disease) at 59 U.S. and Canadian sites. The Seattle meetings featured preliminary analysis of the one-year data.
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Researchers Identify New Function For Protein Missing In Duchenne Muscular Dystrophy

Researchers at the University of Minnesota and National Institutes of Health have identified a new function for the protein missing in people with the most common and ultimately lethal form of childhood muscular dystrophy. Patients with Duchenne muscular dystrophy lack the protein dystrophin, which causes their muscles to become weak and eventually die. Since its discovery in 1987, research has shown that dystrophin protects muscle cells by directly connecting to two of the three filament types that give cells their shape and durability. The new study demonstrates that dystrophin also directly links to the third structural filament type named microtubules. Microtubules form a highly ordered lattice in muscle, and the new study finds that microtubules become disorganized when dystrophin is missing. "It"s remarkable that scientists have been intensively studying dystrophin for more than 20 years, yet we continue to identify new features that better define its important contribution to healthy muscle." said James Ervasti, Ph.D., a professor in the Department of Biochemistry, Molecular Biology & Biophysics, who directed the investigation. The new findings suggest that loss of microtubule organization might contribute to the devastating symptoms of Duchenne muscular dystrophy, information that will hopefully lead to the development of therapies to combat the disease. The study appears online Aug. 3, 2009 and will be published in the Aug. 10 issue of The Journal of Cell Biology. The research was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Patty Mattern University of Minnesota


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