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Scientists Track Chemical Changes In Cells As They Endure Extreme Conditions
One of nature"s most gripping feats of survival is now better understood. For the first time, scientists from the U.S. Department of Energy"s Lawrence Berkeley National Laboratory observed the chemical changes in individual cells that enable them to survive conditions that should kill them.
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Examining The Risk Of Tuberculosis From Arthritis Medication
Treatment with anti-tumor necrosis factor (TNF) agents is recognized as a risk factor for tuberculosis (TB) in patients with immune-mediated inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn"s disease, psoriatic arthritis and psoriasis. Most TB cases develop as a result of reactivation of a latent TB infection, and health authorities worldwide recommend screening for latent TB and treating patients before initiating anti-TNF treatment. A new study examined cases of TB associated with anti-TNF therapy and found that the risk of TB is higher for patients receiving anti-TNF monoclonal antibody therapy (infliximab or adalimumab) than for those receiving soluble TNF receptor therapy (etanercept). The study is published in the July issue of Arthritis & Rheumatism.
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New Indicators Will Help Drive Quality Improvement In The NHS, UK
A list of more than 200 indicators of high quality care in the NHS is being published for the first time to help clinicians drive up the quality of care they deliver to patients, the Department of Health and The NHS Information Centre announced today.
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Latest Updates From The Alzheimer's Disease Neuroimaging Initiative (ADNI)

Alzheimer imaging aficionados thronged to back-to-back meetings held recently in Seattle for a preview of the latest data from the Alzheimer"s Disease Neuroimaging Initiative (ADNI). Launched in the fall of 2004 and set to conclude next year, the $64-million ADNI is comparing imaging methods and fluid biomarkers in the same set of people to determine which measures can best predict and track Alzheimer-disease clinical changes over time. The project is approaching the homestretch of data collection. By the fall of 2010, ADNI scientists will have collected three years of longitudinal data from more than 800 participants (about 200 normal, 400 with mild cognitive impairment (MCI), and 200 with Alzheimer disease) at 59 U.S. and Canadian sites. The Seattle meetings featured preliminary analysis of the one-year data. By and large, ADNI has helped identify a number of precise, clinically meaningful biomarkers that should be able to stand in for slower-to-budge cognitive measures, slashing time and cost from AD drug trials. "I think that ADNI is not only on track for meeting the goals we set out with, but we"ve added so many additional goals," said principal investigator Michael Weiner, University of California, San Francisco, in a post-meeting phone conversation with this reporter. "The whole project has become more ambitious and is having more impact." The Alzheimer Research Forum, founded in 1996, is the web"s most dynamic scientific community dedicated to understanding Alzheimer disease and related disorders. Access to the web site is free to all. The Forum"s editorial priorities are as diverse as the needs of the research community. The web site reports on the latest scientific findings, from basic research to clinical trials; creates and maintains public databases of essential research data and reagents; and produces discussion forums to promote debate, speed the dissemination of new ideas, and break down barriers across the numerous disciplines that can contribute to the global effort to cure Alzheimer"s disease. The Alzheimer Research Forum is an independent nonprofit organization supported by grants and individual donations. The web site does not endorse any specific product or scientific approach. Alzheimer Research Forum Foundation


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