Popular Articles

Is It Time To Consider A Role For MRI Before Prostate Biopsy?
UroToday.com - The prevailing view is that MRI has a limited role in the management of prostate cancer. Currently, the threshold for requesting a pre-treatment staging MRI is variable with most advocating this for only those classified as high risk localized prostate cancer, although some also advocate men with intermediate risk disease.
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HIV Transmission In Europe Occurs Primarily In Vacation Destinations, Study Finds
HIV in Europe is transmitted primarily in vacation destinations, according to a study published recently in the journal Retrovirology, the PA/Google.com reports. For the study, researchers led by Dimitrios Paraskevis of the University of Athens analyzed samples of HIV-1 subtype B virus, the most prevalent form of HIV in Europe, from 16 European countries and Israel (PA/Google.com, 5/20). The researchers created a family tree of the virus and examined its genetic characteristics to determine how it has evolved.The study found that tourists are more likely to contract HIV in Greece, Portugal, Serbia and Spain, which are popular vacation destinations. Meanwhile, HIV-positive people in Austria, Belgium, Denmark and Luxembourg are more likely to have contracted the virus outside of these countries. The study also found that HIV-positive people in Israel, Norway, the Netherlands, Sweden, Switzerland and the United Kingdom contract the virus both within these countries and in other countries. In addition, the study found that in Poland the virus spread mainly among residents through injection drug use. "Viruses move around with travelers -- thus health programs within countries should not only target the national populations, prevention efforts must also be aimed at migrants, travelers and tourists -- who are both major s and targets of HIV," Paraskevis said (BBC News, 5/20). Lisa Power, head of policy at the Terrence Higgins Trust, said that the findings are not a "surprise," adding, "We"ve known for some time with high levels of mobility in the world these days that it"s very easy for viruses to move around. What it tells us is that you can"t limit HIV prevention and support just to permanent residents" (PA/Google.com, 5/20).
News of the day
Somnia Anesthesia: 3rd Study Confirms Anesthesia Improves Outcomes In Colonoscopies
More pre-cancerous polyps were found in colonoscopies performed with deep sedation primarily using Propofol than with milder sedation in which patients remained conscious, according to a recent study conducted by Katherine Hoda, M.D. of Oregon Health and Science University. This improvement in cancer detection will save lives and reduce the number of patients requiring surgery and chemotherapy.
Oncology

Childhood Epilepsy Tackled By Rutgers Research

Rutgers researchers have discovered a potential new way to treat childhood epilepsy using a widely available therapeutic drug. Rutgers neuroscientist Gabriella D"Arcangelo and her colleagues have published their research findings in the journal Disease Models and Mechanisms (in press) and the paper has just appeared online. In their quest for new therapeutic approaches, the researchers are investigating the molecular basis of the disease. The article describes the first use of a mouse model of cortical dysplasia, a malformation of the brain that is most often the cause of childhood epilepsy. Introducing the drug rapamycin, originally used to prevent rejection in organ transplants, suppressed epileptic seizures in the mice. Epilepsy is the third most common neurological disorder in the United States after Alzheimer"s disease and stroke. It currently affects more than 326,000 children under age 15. More than 90,000 of them have severe seizures that cannot be adequately treated. The children often go on to develop cognitive problems due to recurrent and uncontrolled seizures and the combined effects of heavy medication. They may also suffer consequences from having parts of their brains removed during surgery. According to the International League Against Epilepsy (ILAE), approximately 45 percent of the pediatric epilepsy surgery cases (patients under age 18) are due to cortical dysplasia. A staggering 75 percent of surgery patients under age 2 have the condition. "The surgery is not without risks, and while it may help control the seizures, it does not work in all cases," said D"Arcangelo, an associate professor in the Department of Cell Biology and Neuroscience at Rutgers, The State University of New Jersey. "Clearly there is a pressing need to come up with new strategies for treatment." D"Arcangelo"s mutant mice lack a gene (Pten) that suppresses cell growth in some neurons, resulting in these mutants displaying molecular, cellular and physiological traits of cortical dysplasia. The researchers treated the mice with rapamycin. It had already shown promise in a different mouse model for treating tuberous sclerosis complex (TSC), a subtype of cortical dysplasia. "We demonstrated that rapamycin is a novel and effective anti-epileptic agent that suppresses seizures in our mice, as well as in the TSC model, and this has raised some hope for the future," said D"Arcangelo. "This drug is being tested on human patients of tuberous sclerosis in a multicenter study involving six TSC clinics throughout the United States. I hope it will soon be tested for all cortical dysplasia patients." Joseph Blumberg Rutgers University


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