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Analysis Of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen In Once-Daily Dosing
A sub-analysis of a Phase IIb multinational study(1) with edoxaban(2) - an investigational oral Factor Xa inhibitor - provides insights into why patients with non-valvular atrial fibrillation (AF) receiving edoxaban once daily (QD) experienced fewer bleeding events than patients given edoxaban twice a day (BID). The analysis finds that bleeding associated with edoxaban is most closely correlated with minimum concentration levels of the drug in the blood, and that these trough levels may best predict bleeding events, rather than total exposure or maximum concentration levels.
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Metabolic Factors May Play A Role In Risk For Breast Cancer
Physiological changes associated with the metabolic syndrome may play a role in the risk of postmenopausal breast cancer, according to study results published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
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Sinovac Provides Update On Clinical Trial For H1N1 Vaccine Trials
Sinovac Biotech Ltd. (NYSE AMEX: SVA), a leading provider of vaccines in China, announced today that the clinical trial of its A/H1N1 influenza vaccine is proceeding well. All of the volunteers have received their first shot of the vaccine and, during the three-day observation of safety, the preliminary tests on the A/H1N1 influenza vaccine have indicated that the vaccine is safe and reliable in humans.
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California Gov. Schwarzenegger's Plan To Reduce State Spending Includes Cuts To HIV/AIDS Services

California Gov. Arnold Schwarzenegger (R) on Tuesday sent state lawmakers a plan to reduce more than $5 billion in spending that includes cuts to HIV/AIDS services, the Los Angeles Times reports (Rothfeld/McGreevy, Los Angeles Times, 5/27). The proposed cuts include $55.5 million in California"s AIDS Drug Assistance Program and other state Office of AIDS programs. According to the San Francisco Chronicle, Schwarzenegger"s plan would make HIV-positive people pay more for drugs, while HIV/AIDS programs such as counseling, monitoring and education would be reduced or eliminated. "We were expecting cuts, but this is much, much worse than what we were expecting," Courtney Mulhern-Pearson, policy and legislative associate for the San Francisco AIDS Foundation, said (Yi, San Francisco Chronicle, 5/27). Tuesday"s plan follows a separate proposal to cut $16 billion in overall state spending that Schwarzenegger announced two weeks ago. Aides say that Schwarzenegger plans to propose an additional $3 billion in reductions by the end of the week to offset a projected $24.3 billion budget shortfall. "Behind every one of these dollars that we cut there are real faces," Schwarzenegger said, adding, "Even though those are tough choices, what is the alternative?" (Los Angeles Times, 5/27). Reprinted with kind permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation. © 2009 Advisory Board Company and Kaiser Family Foundation. All rights reserved.


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