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In Synaptic Process Protein 'Tweek' Rare But Critical
Recycling is a critical component in the process of transmitting information from one neuron to the next, and a large protein called Tweek plays a critical role, said an international consortium of researchers led by Baylor College of Medicine in a report in the current issue of the journal Neuron.
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Medtronic Clinical Trial Evaluating The Newest Radiofrequency Ablation Tools For Atrial Fibrillation Completes Enrollment
Medtronic, Inc. (NYSE:MDT) announced completion of enrollment in the TTOP-AF (Tailored Treatment of Permanent Atrial Fibrillation) clinical trial. The study is evaluating the use of the latest radiofrequency (RF) ablation technology, the Medtronic Ablation Frontiers Cardiac Ablation System, for the treatment of continuous atrial fibrillation (AF). A leading advancement from currently available RF ablation tools, the system is comprised of a RF generator (or energy ) and three anatomically shaped mapping and ablation catheters that target three areas of the heart for AF treatment. The system is approved for use in Europe and is under investigational use in the United States.
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White House Submits Sotomayor's Questionnaire To Senate Judiciary Committee
The Senate Judiciary Committee"s vetting of Judge Sonia Sotomayor, President Obama"s nominee for the Supreme Court, officially began Thursday when the White House delivered her written responses to a comprehensive questionnaire designed by the committee"s leadership, Roll Call reports. The questionnaire -- developed by Committee Chair Patrick Leahy (D-Vt.) and ranking member Jeff Sessions (R-Ala.) -- will be used as part of preparations for Sotomayor"s as-yet-unscheduled round of confirmation hearings (Stanton, Roll Call, 6/4).Sotomayor disclosed a large amount of information in the questionnaire, such as her net worth and a timeline for when she learned that she was under consideration by the White House as a potential replacement to retiring Supreme Court Justice David Souter (Perine, CQ Today, 6/4). According to Roll Call, Sotomayor"s responses might offer members of both parties "fodder to support or oppose her nomination."Leahy, who has the authority to schedule the confirmation hearings, said in a statement that Sotomayor "has advanced the confirmation process by promptly complying with this Senate requirement, and now the Senate should promptly schedule hearings to fairly consider her nomination to our highest court," adding, "The unfair attacks that have been leveled at her from outside the Senate are all the more reason to give her the chance to respond." Earlier this week, he said that he would announce a start date for the hearings after Sotomayor"s responses were received (Roll Call, 6/4). Meanwhile, Sotomayor on Thursday continued another round of private meetings with senators on Capitol Hill, including a few GOP senators who earlier had expressed concerns about her past comments and actions, CQ Today reports (CQ Today, 6/4).Questions Over Sotomayor"s Position on Abortion-Rights Issue RemainIn related news, USA Today on Friday examined how Sotomayor in the past 17 years as a federal judge "has left no clear footprints revealing" her position on abortion-rights issues. This week, some Democratic senators in private meetings with Sotomayor attempted to seek answers, while advocates on both sides of the debate are urging senators to question her about her views on Roe v. Wade during the expected confirmation hearings. On Wednesday, following a meeting with Sotomayor, Sen. Dianne Feinstein (D-Calif.) said that she believes Sotomayor has respect for judicial precedent. Nancy Northup, president of the Center for Reproductive Rights, said, "I don"t have concerns about this nominee in the sense that I think there is something on the record (against abortion rights)," adding, "We just think it"s important for Supreme Court nominees to say where they stand." Charmaine Yoest, president of Americans United for Life, agreed, noting the lack of a definitive position on abortion rights in Sotomayor"s record. Feinstein also said that she will persist on abortion-rights issues. "I remember what it was like when abortion was illegal, and the lives of young, desperate women were in jeopardy," she said, adding that she is concerned "Americans no longer appreciate what it would mean if (abortion rights) were taken away" (Biskupic, USA Today, 6/5).
Medical Devices

British Medical Journal Examines Recent Progress In Treating Neglected Diseases

The British Medical Journal examines the outcome of the Drugs for Neglected Diseases initiative meeting held in Nairobi, Kenya, last week. More than 200 international health experts came together to discuss finding therapies for such diseases as visceral leishmaniasis, Chagas disease and sleeping sickness. "Current treatments are often toxic, prohibitively expensive, or difficult to administer in countries with limited res," and "[d]rug companies have little incentive to develop treatments for neglected diseases that mainly affect poor people," the journal writes. Developing countries have "the ability to provide new solutions for neglected diseases, but every day we face an uphill battle to find home grown capacity for research and development into diseases that affect our poor," said Monique Wasunna of the Kenya Medical Research Institute, adding, "By working together in regional, needs-driven research platforms, we have been able to do more in the past five years than had been done in the previous 20 years." The article examines the recent progress in the area of neglected diseases research around the world, including new treatment options for disease and partnerships for drug discovery and development (Tanne, 6/29). WHO Experts To Discuss Ways To Fund Neglected Disease Research, Drug Development Intellectual Property Watch explores ways to pay for research and clinical trials for treatments of neglected diseases, "even when the consumer demand is small and [the] constituents poor." The topic will be front and center during a meeting of the Expert Working Group on Research and Development Financing, "which is seen by many governments and nongovernmental organisations as a key outcome of the WHO global strategy and plan of action on public health, innovation and intellectual property" (Mara, 6/29). This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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