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Reprogrammed Mouse Fibroblasts Can Make A Whole Mouse
In a paper publishing online July 23 in Cell Stem Cell, a Cell Press journal, Dr. Shaorong Gao and colleagues from the National Institute of Biological Sciences in Beijing, China, report an important advance in the characterization of reprogrammed induced pluripotent stem cells, or iPSCs.
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Prevalence Of Variant CJD Agent In Britain Remains Uncertain
First results from a large tissue survey in Britain of the agent that causes variant Creutzfeldt-Jakob disease (vCJD) are unable so far to establish that the prevalence is lower than that given by previous estimates, concludes a study published on bmj.com today.
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Health Officials Issue Revised Pregnancy Weight-Gain Guidelines For Obese Women
The Institute of Medicine and the National Research Council on Thursday issued revised U.S. weight-gain guidelines for obese pregnant women, in response to rising levels of obesity in the country and growing evidence that weight gain can cause health problems for women and their infants, the New York Times reports. The revision, which is the first since 1990, recommends that obese women -- those with a body mass index of 30 or more -- limit their weight gain to 11 to 20 pounds over nine months. The 1990 pregnancy guidelines did not specifically address weight gain for obese women, telling them instead to follow the recommendations for overweight women. According to health officials, the changes to the recommendations for obese women were required to keep up with the changing weight patterns among women in the U.S. The New York Times reports that about 27% of women of childbearing age are considered obese, while 55% fall into the categories of overweight or obese.The recommendations for women with BMIs of less than 30 did not change. They call for overweight women -- those with a BMI of 25 to 29.9 -- to gain 15 to 25 pounds over nine months, while underweight women -- with BMIs of less than 18.5 -- should gain 28 to 40 pounds, and normal-weight women -- with BMIs of 18.6 to 24.9 -- should gain 25 to 35 pounds (Parker-Pope, New York Times, 5/29).Time reports that pregnant women who do not gain enough weight face a higher risk of stunted fetal growth and preterm delivery. However, it is more common for women to gain too much weight, placing them at higher risk for conditions like gestational diabetes and high blood pressure. In addition, their infants are at increased risk of being born earlier, larger and by cesarean section. Time reports that excessive weight gain can increase a woman"s risk of postpartum obesity and elevate risks of heart disease and stroke because most women do not lose extra pounds gained during pregnancy. Many studies also have suggested that a woman"s gestational weight can predict potential weight problems in her offspring (Kingsbury, Time, 5/28).The committee that developed and issued the revision said that the existing guidelines were essentially on target but that women and their physicians need to work harder to help women reach a normal weight before pregnancy and avoid gaining too much weight during pregnancy, according to the Los Angeles Times (Roan, Los Angeles Times, 5/29). The guidelines also recommend more nutrition and exercise counseling during pregnancy, advising physicians or midwives to consult dieticians to shape a woman"s care regardless of her initial weight, the AP/Yahoo! News reports (Neergaard, AP/Yahoo! News, 5/28). The Los Angeles Times reports that health care professionals are expected to recognize and implement some of the recommendations; however, it is not mandatory to do so.Several experts on maternal obesity and child health expressed disappointment with the guidelines, arguing that obese women should gain little to no weight during pregnancy, according to the Los Angeles Times. They also argue the new guidelines do not do enough to address obesity before pregnancy. Maxine Hayes, state health officer for the Washington State Department of Health, said, "If we wait for every woman to be advised about weight gain after they become pregnant, it"s too late. It puts women and their babies on a trajectory that is unhealthy" (Los Angeles Times, 5/29).
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Between 1992 And 2005 Survival Rates For Elderly Receiving Hospital CPR Did Not Improve

A study of elderly patients receiving CPR in the hospital shows that rates of survival did not improve from 1992 to 2005. During that period, the proportion of hospital deaths preceded by CPR rose, and the proportion of patients who were successfully resuscitated and later discharged home fell. The researchers found that 18.3 percent of the Medicare beneficiaries age 65 and older who underwent in-hospital CPR survived to discharge. Elderly black patients were more likely to receive CPR, but less likely to survive, partially because they were more likely to be treated in hospitals with lower rates of post-CPR survival and perhaps more likely to request that resuscitation be attempted, according to the report published in The New England Journal of Medicine. The adjusted odds for survival for black elderly patients were 23.6 percent lower than for similar white patients. Older age, being a man, having more co-existing chronic illnesses, and residing in a skilled nursing facility before hospitalization also lessened the chances of survival, according to this study"s findings. Higher income did not improve survival. The researchers looked at records of 433,985 patients who both received CPR in U.S. hospitals from 1992 to 2005 and had Medicare coverage through the Old-Age and Survivors Insurance Fund, but who were not recipients of Social Security Disability Income or enrolled in an HMO. The first author of the study is Dr. William J. Ehlenbach, senior fellow, Division of Pulmonary and Critical Care Medicine at Harborview Medical Center and the University of Washington (UW) in Seattle, and the senior author is Dr. Renee D. Stapleton, formerly of the UW and now at the Division of Pulmonary Care, University of Vermont College of Medicine. "CPR has become the default response to cardiac arrest in or out of the hospital," the researchers noted. The authors conducted the study because it was unclear whether advances in CPR or in care after cardiac arrest have improved outcomes. "Of significant concern," they wrote, "is our finding that the proportion of patients who died in the hospital after previously having undergone in-hospital CPR has increased during a time of more education and awareness of the limits of CPR in patients with advanced chronic illness and life-threatening acute illness." They added that although Do Not Attempt Resuscitation orders became more common during the 1980s, their availability has not effectively decreased the frequency of administering CPR to patients who are unlikely to benefit. One possibility for their findings, the researcher noted, is that attempts to enhance the delivery of CPR have been less successful than changes in out-of-hospital resuscitation efforts, such as bystander CPR and automatic defibrillators, trained emergency response units, and dispatchers providing CPR instruction over the phone, that have contributed to improved survival. The findings might also reflect changes over the years in the type and severity of illness, the underlying causes of the cardiac arrest, or the initial heart rhythm abnormality that made the heart stop beating. For example, people whose cardiac arrest occurs from ventricular fibrillation or fluttering or from an abnormally rapid heart rate are more likely to survive than someone whose heart shows pulseless electrical activity. In addition, heart disease has declined in the United States, but critical illnesses such as severe sepsis leading to irreversible shock have increased. The researchers also found that patients who were successfully resuscitated and later discharged were more likely to be sent to a health-care facility than to return home. They added that this finding might reflect the trend toward shorter hospital stays or it could be due to neurological or functional damage from the cardiac arrest. A limitation of the study, according to the researchers, is that the Medicare claims data do not contain potential predictors of survival after CPR, such as severity and type of underlying illness, the type of heart rhythm problem preceding cardiac arrest, patient location in hospital, and time to defibrillations. Knowing such factors, they explained, may also help in understanding differences in survival associated with race and hospital. The researchers hope the study provides information useful to older patients and their doctors when deciding whether to choose to attempt resuscitation. They also hope their findings stimulate efforts to understand the association between race and survival to eliminate disparities, and to learn more about the specific factors associated with the incidence of CPR and the rate of survival for patients of all races. In addition to Ehlenbach and Stapleton, the study authors are Dr. Amber E. Barnato, Department of Medicine, University of Pittsburgh; Dr. J. Randall Curtis, Division of Pulmonary and Critical Care, Harborview and UW School of Medicine; Dr. William Kreuter, UW Comparative Effectiveness Costs and Outcomes Research Center; Dr. Thomas D. Koepsell, Department of Epidemiology, UW School Public Health; and Dr. Richard A. Deyo, Department of Family Medicine and Medicine, Oregon Health Sciences University. The research was funded by a Physicians Geriatric Development Research Award from the American College of Physicians CHEST Foundation, Atlantic Philanthropies, the John A. Hartford Foundation and the Association of Specialty Professors; a National Center for Research Roadmap Award and additional awards from the National Institutes of Health; and a Centers of Biomedical Research Excellence Award. Leila Gray University of Washington


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