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Altair Therapeutics Reports Successful Completion Of Phase I Study Of Inhaled AIR645
Altair Therapeutics, Inc., a privately-held, biopharmaceutical company developing novel therapeutics for respiratory diseases, reported results from its phase I study evaluating the safety, tolerability and pharmacokinetics of its lead product, once-weekly inhaled AIR645, in healthy volunteers. AIR645 is a non-steroidal dual inhibitor of cellular responses to interleukin (IL)-4 and IL-13, cytokines that play a critical role in development and progression of asthma, rhinitis and other allergic disorders. Results presented today at the 2009 International Conference of the American Thoracic Society (ATS) within the Mini-Symposium "New Treatment Approaches for Asthma and Allergy" showed that inhaled AIR645 was safe, well tolerated and had dose-dependent exposure in the airways. These results demonstrate the potential of AIR645 as a convenient once-weekly treatment for asthma and other respiratory disorders. Later this year, Altair plans to initiate a phase II efficacy study in patients with asthma.
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Families Of Sudden Unexplained Death Victims Should Receive Comprehensive Cardiogenetic Testing
Relatives of a young person who dies suddenly should always be referred for cardiological and genetic examination in order to identify if they too are at risk of sudden death, a scientist told the annual conference of the European Society of Human Genetics. Dr. Christian van der Werf, a research fellow at the Department of Cardiogenetics, Academic Medical Centre, Amsterdam, The Netherlands said that, although his team"s research showed that inherited heart disease was present in over 30% of the families of sudden unexplained death (SUD) victims, the majority of such relatives were currently not being referred for examination.
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Health System Lessons From Black Saturday
The Victorian hospital system coped well in the wake of the Black Saturday bushfires of February 2009 but new research, published in the Medical Journal of Australia, suggests the lessons learned over this time must be used to further strengthen the State"s prevention and medical response systems.
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Active Commuters Have Fewer Heart Disease Risk Factors

Men and women who walk or ride a bike to work appear more fit, and men are less likely to be overweight or obese and have healthier triglyceride levels, blood pressure and insulin levels, according to a report in the July 13 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. For most adults, 60 minutes of brisk walking per day is sufficient to meet physical activity guidelines for avoiding weight gain, according to background information in the article. "One potentially effective means of increasing physical activity is through alternative, non-leisure forms of physical activity such as active commuting (walking or biking to work)," the authors write. However, little previous research has been conduced on the cardiovascular and overall health benefits of such lifestyle exercise. Penny Gordon-Larsen, Ph.D., of the School of Public Health, University of North Carolina at Chapel Hill, and colleagues studied 2,364 adults in the Coronary Artery Risk Development in Young Adults (CARDIA) study who worked outside the home. At examinations conducted between 2005 and 2006, participants reported the length of their commute in minutes and miles, including details on the percentage of the trip taken by car, public transportation, walking or bicycling. The participants" height, weight and other health variables, including blood pressure and fitness levels as assessed by a treadmill test, also were collected. In addition, they wore an accelerometer to measure their levels of physical activity during at least four days of the study period. A total of 16.7 percent of the participants used any means of active commuting to reach their workplace. "Active commuting was positively associated with fitness in men and women and inversely associated with body mass index, obesity, triglyceride levels, blood pressure and insulin level in men," the authors write. The results add to existing evidence that walking or biking to work is beneficial, they note. "Public support for policies that encourage active commuting has been shown, particularly for individuals with experience using active commuting and with positive attitudes toward walking and biking," the authors write. "Furthermore, increasing active commuting will have the dual benefits of increasing population health and in reduction of greenhouse gas emissions. Environmental supports for commuting, such as physical environment and sociocultural factors, have been shown to promote active forms of commuting." Additional research is needed to elucidate other potential benefits of active commuting, as well as unraveling the association between walking or biking to work and other health-promoting behaviors, they conclude. Arch Intern Med. 2009;169[13]:1216-1223. Archives of Internal Medicine


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